Mannitol.
نویسندگان
چکیده
Mannitol may be useful clinically both as a diuretic and as an obligate extracellular solute. As a diuretic it can be used to treat patients with intractable edema states, to increase urine flow and flush out debris from the renal tubules in patients with acute tubular necrosis, and to increase toxin excretion in patients with barbiturate, salicylate or bromide intoxication. As an obligate extracellular solute it may be useful to ameliorate symptoms of the dialysis disequilibrium syndrome, to decrease cerebral edema following trauma or cerebrovascular accident, and to prevent cell swelling related to renal ischemia following cross-clamping of the aorta. Largely unexplored uses for mannitol include its use as an osmotic agent in place of dextrose in peritoneal dialysis solutions, its use to maintain urine output in patients newly begun on hemodialysis, and its use to limit infarct size following acute myocardial infarction.
منابع مشابه
Evaluation of the role of mannitol in radaioprotection of amifostine
Background: Mannitol is present in the Ethyol ® (the trade name of amifostine) as an excipient. The mechanism of radioprotection of amifostine is radical scavenging. Since mannitol is another known radical scavenger, we studied the probable additive or synergistic effect of mannitol on the effect of amifostine. Material and Methods: Mice were irradiated with Co-60 γ -ray in the presence 400mg/k...
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The present paper deals with the kinetics and mechanism of homogeneously Ir(III) chloride catalyzed oxidation of D-mannitol by chloramine-T [CAT] in perchloric acid medium in the temperature range of 30 to 45 0C. The reaction is carried out in the presence of mercuric acetate as a scavenger for chloride ion. The experimental results show first order kinetics with respect to the oxidant [CAT] an...
متن کاملP-177: Effect of Mannitol Therapy Protocol on Ovarian Hyperstimulation Syndrome Management;Comparison between PCO and Non-PCO Patients
متن کامل
Mannitol metabolism during pathogenic fungal–host interactions under stressed conditions
Numerous plants and fungi produce mannitol, which may serve as an osmolyte or metabolic store; furthermore, mannitol also acts as a powerful quencher of reactive oxygen species (ROS). Some phytopathogenic fungi use mannitol to stifle ROS-mediated plant resistance. Mannitol is essential in pathogenesis to balance cell reinforcements produced by both plants and animals. Mannitol likewise serves a...
متن کاملMannitol oxidation in two Micromonospora isolates and in representative species of other actinomycetes.
Mannitol kinase and mannitol-1-phosphate dehydrogenase activities were detected in two Micromonospora isolates. The presence of these enzyme activities indicates that mannitol is catabolized first to mannitol-1-phosphate and then to fructose-6-phosphate. Mannitol-oxidizing enzymes were also surveyed in representative species of four other genera of actinomycetes. Mannitol-1-phosphate dehydrogen...
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ورودعنوان ژورنال:
- The Western journal of medicine
دوره 131 4 شماره
صفحات -
تاریخ انتشار 1979